Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892355 | 1.00 | PRMT5 (0.33) | PRMT5WDR77BCHE | |
| SCHEMBL23892209 | 0.92 | PRMT5 (0.31) | PRMT5WDR77BCHE | |
| SCHEMBL23892460 | 0.91 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL23892199 | 0.89 | PRMT5 (0.37) | PRMT5WDR77BCHE | |
| SCHEMBL23892696 | 0.84 | PRMT5 (0.44) | PRMT5WDR77BCHE | |
| SCHEMBL25950844 | 0.84 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL22002270 | 0.80 | PRMT5 (0.38) | PRMT5WDR77 | |
| SCHEMBL23892495 | 0.77 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL23892492 | 0.77 | PRMT5 (0.35) | PRMT5WDR77 | |
| SCHEMBL23892321 | 0.75 | PRMT5 (0.43) | PRMT5WDR77BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |