Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25955859 | 0.84 | PRMT5 (0.47) | PRMT5WDR77METTL3 | |
| SCHEMBL23892199 | 0.81 | PRMT5 (0.37) | PRMT5WDR77METTL3 | |
| SCHEMBL18572265 | 0.81 | PRMT5 (0.41) | PRMT5WDR77METTL3NPC1RAB9A | |
| SCHEMBL25950844 | 0.80 | PRMT5 (0.35) | PRMT5WDR77METTL3 | |
| SCHEMBL23892495 | 0.79 | PRMT5 (0.39) | PRMT5WDR77METTL3 | |
| SCHEMBL23892478 | 0.79 | METTL3 (0.37) | PRMT5WDR77METTL3 | |
| SCHEMBL25950780 | 0.79 | METTL3 (0.37) | PRMT5WDR77METTL3 | |
| SCHEMBL23892355 | 0.77 | PRMT5 (0.33) | PRMT5WDR77 | |
| SCHEMBL25950438 | 0.77 | PRMT5 (0.33) | PRMT5WDR77 | |
| SCHEMBL23892209 | 0.76 | PRMT5 (0.31) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |