Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18338533 | 0.77 | DRD2 (0.36) | DRD2DRD4DRD3 | |
| SCHEMBL24945545 | 0.77 | DRD2 (0.36) | DRD2DRD4DRD3 | |
| SCHEMBL29297366 | 0.75 | DRD2 (0.42) | DRD2DRD4DRD3 | |
| SCHEMBL25951094 | 0.74 | DRD2 (0.35) | DRD2DRD4DRD3 | |
| SCHEMBL26114431 | 0.73 | DRD2 (0.33) | DRD2DRD4DRD3 | |
| SCHEMBL18338606 | 0.72 | DRD2 (0.34) | DRD2DRD4DRD3 | |
| SCHEMBL24566440 | 0.72 | DRD2 (0.34) | DRD2DRD4DRD3 | |
| SCHEMBL22200763 | 0.72 | DRD2 (0.57) | DRD2DRD4DRD3NOS3NOS1 | |
| SCHEMBL30406244 | 0.70 | CYP1A2 (0.32) | DRD2DRD4DRD3 | |
| SCHEMBL20412507 | 0.70 | DRD2 (0.32) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555070-B1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | EPIZYME INC (US) | 2023-08-09 | — | — | EP | disclosed |