Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892588 | 0.93 | EPHA2 (0.31) | EPHA2PDPK1 | |
| SCHEMBL23892378 | 0.86 | PDPK1 (0.35) | EPHA2PDPK1BACE1 | |
| SCHEMBL22002273 | 0.82 | RXFP1 (0.33) | PDPK1 | |
| SCHEMBL18571910 | 0.80 | PRMT5 (0.38) | — | |
| SCHEMBL23892620 | 0.79 | PDPK1 (0.35) | EPHA2PDPK1BACE1 | |
| SCHEMBL25950980 | 0.79 | PDPK1 (0.35) | EPHA2PDPK1BACE1 | |
| SCHEMBL25951083 | 0.78 | PRMT5 (0.36) | — | |
| SCHEMBL18571906 | 0.76 | PRMT5 (0.37) | PDPK1 | |
| SCHEMBL18572601 | 0.75 | PDPK1 (0.32) | PDPK1 | |
| SCHEMBL23892279 | 0.75 | PRMT5 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |