Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29958837 | 0.74 | CDK8 (0.43) | HDAC8MKNK2ATMHASPINCDC7 | |
| SCHEMBL256359 | 0.74 | CDK8 (0.43) | HDAC8MKNK2ATMHASPINCDC7 | |
| SCHEMBL31298606 | 0.69 | HDAC8 (0.40) | SLC6A2HDAC8MKNK2CYP2A6ATM | |
| SCHEMBL31298637 | 0.69 | HDAC8 (0.37) | HDAC8MKNK2CYP2A6ATMHASPIN | |
| SCHEMBL12775602 | 0.69 | CYP17A1 (0.41) | HDAC8MKNK2ATMHASPINTGFBR1 | |
| SCHEMBL19258536 | 0.69 | HASPIN (0.53) | SLC6A2HDAC8MKNK2HASPINCDK2 | |
| SCHEMBL16339750 | 0.69 | HDAC8 (0.47) | HDAC8MKNK2ATMHASPINTGFBR1 | |
| SCHEMBL29520621 | 0.67 | SLC6A2 (0.63) | SLC6A2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL17785797 | 0.67 | HDAC8 (0.42) | HDAC8MKNK2LMNA | |
| SCHEMBL4140238 | 0.67 | CHEK1 (0.57) | HDAC8MKNK2HASPINCDC7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555070-B1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | EPIZYME INC (US) | 2023-08-09 | — | — | EP | disclosed |