Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | MMP2 | P08253 | 4/20 | 0.31 |
| ▸ | MMP3 | P08254 | 4/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
| ▸ | LIPC | P11150 | 2/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594110 | 0.89 | GPR119 (0.38) | GPR119 | |
| SCHEMBL2593747 | 0.85 | GPR119 (0.38) | GPR119 | |
| SCHEMBL14729043 | 0.79 | GPR119 (0.42) | GPR119 | |
| SCHEMBL14729040 | 0.78 | GPR119 (0.43) | GPR119 | |
| SCHEMBL2595250 | 0.78 | GPR119 (0.39) | GPR119 | |
| SCHEMBL14729038 | 0.77 | GPR119 (0.38) | GPR119 | |
| SCHEMBL2594012 | 0.75 | GPR119 (0.35) | GPR119MMP2MMP3LIPCLIPG | |
| SCHEMBL14729050 | 0.74 | GPR119 (0.42) | GPR119MMP2MMP3 | |
| SCHEMBL14718719 | 0.74 | GPR119 (0.38) | GPR119MMP2MMP3MAPTLIPG | |
| SCHEMBL14718640 | 0.73 | GPR119 (0.52) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566860-A1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140160-A1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-11-10 | — | — | WO | disclosed |