Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 10/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 10/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892310 | 1.00 | METTL3 (0.52) | METTL3PRMT5WDR77ALDH1A1CYP1A2 | |
| SCHEMBL22683155 | 1.00 | METTL3 (0.52) | METTL3PRMT5WDR77ALDH1A1CYP1A2 | |
| SCHEMBL22685214 | 0.93 | METTL3 (0.45) | METTL3PRMT5WDR77 | |
| SCHEMBL23892293 | 0.93 | METTL3 (0.45) | METTL3PRMT5WDR77 | |
| SCHEMBL23892406 | 0.90 | PRMT5 (0.53) | METTL3PRMT5WDR77 | |
| SCHEMBL23892345 | 0.88 | PRMT5 (0.46) | METTL3PRMT5WDR77 | |
| SCHEMBL23892664 | 0.88 | PRMT5 (0.46) | METTL3PRMT5WDR77 | |
| SCHEMBL25958510 | 0.83 | PRMT5 (0.48) | METTL3PRMT5WDR77 | |
| SCHEMBL18572972 | 0.82 | METTL3 (0.76) | METTL3PRMT5WDR77 | |
| SCHEMBL18571729 | 0.82 | PRMT5 (0.41) | METTL3PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |