Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26762536 | 0.79 | HRH3 (0.42) | SMN1; SMN2LMNACHRM2CHRM1HTT | |
| SCHEMBL4634677 | 0.70 | — | — | |
| SCHEMBL16270668 | 0.69 | CHRM2 (0.54) | SMN1; SMN2CHRM2CHRM1TSHRCYP2D6 | |
| SCHEMBL2735673 | 0.69 | CHRM2 (0.54) | SMN1; SMN2CHRM2CHRM1TSHRCYP2D6 | |
| SCHEMBL31046804 | 0.69 | CYP2D6 (0.54) | SMN1; SMN2CHRM2CHRM1TSHRCYP2D6 | |
| SCHEMBL2605879 | 0.68 | CYP2D6 (0.49) | SMN1; SMN2LMNACHRM2CHRM1HTT | |
| SCHEMBL18082509 | 0.68 | CHRM2 (0.41) | SMN1; SMN2LMNACHRM2CHRM1HTT | |
| SCHEMBL27270074 | 0.68 | CYP2D6 (0.53) | SMN1; SMN2LMNATSHRCYP2D6OPRM1 | |
| Hydrochloric Acid SCHEMBL27269783 | 0.67 | CYP2D6 (0.51) | SMN1; SMN2LMNATSHRCYP2D6OPRM1 | |
| SCHEMBL23107240 | 0.66 | P2RX7 (0.35) | OPRM1OGAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147594-A2 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |