SCHEMBL25955541

SCHEMBL25955541

C[C@H]1CC=C(c2ccc3sc([C@H]4C[C@@H]5CN(C)C[C@@H]5C4)nc3c2)N(C(=O)OC(C)(C)C)C1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LIPC P11150 1/20 0.32
LIPG Q9Y5X9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32689303 1.00 LIPC (0.32) LIPCLIPG
SCHEMBL29477779 1.00 LIPC (0.32) LIPCLIPG
SCHEMBL25336690 0.97 LIPC (0.31) LIPCLIPG
SCHEMBL25336684 0.97 LIPC (0.31) LIPCLIPG
SCHEMBL25922186 0.93 LIPC (0.33) LIPCLIPG
SCHEMBL25922177 0.93 LIPC (0.33) LIPCLIPG
SCHEMBL25323037 0.92 LIPC (0.32) LIPCLIPG
SCHEMBL25323034 0.92 LIPC (0.32) LIPCLIPG
SCHEMBL32689233 0.91 LIPC (0.33) LIPCLIPG
SCHEMBL24364903 0.91 LIPC (0.33) LIPCLIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240228478-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-07-11 US disclosed
WO-2023146989-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240228478-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 LIPC 815/4885LIPG 2618/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.