LIPC

Hepatic triacylglycerol lipase

9,242 patent compounds predicted against LIPC, 5,620 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL470957	0.55	9/20
SCHEMBL4513736	0.40	8/20
SCHEMBL4513754	0.40	8/20
SCHEMBL4513765	0.40	8/20
SCHEMBL1410556	0.57	7/20
SCHEMBL1410600	0.55	7/20
SCHEMBL1410173	0.54	7/20
SCHEMBL1410555	0.53	7/20
Potassium Ion (SCHEMBL1410609)	0.53	7/20
SCHEMBL1410172	0.51	7/20
SCHEMBL1410302	0.50	7/20
SCHEMBL1410148	0.49	7/20
Potassium Ion (SCHEMBL1410626)	0.41	7/20
SCHEMBL3662750	0.57	6/20
SCHEMBL1410693	0.45	6/20
SCHEMBL1410729	0.46	5/20
SCHEMBL1885177	0.44	5/20
SCHEMBL477818	0.54	4/20
SCHEMBL477819	0.54	4/20
SCHEMBL1409535	0.47	4/20

Germline variants in LIPC on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full LIPC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to LIPC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients	PHASE4	WITHDRAWN
Niacin, N-3 Fatty Acids and Insulin Resistance	PHASE4	COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency	PHASE2/PHASE3	COMPLETED
Comparing Effects of Liraglutide and Bariatric Surgery on Weight Loss, Liver Function, Body Composition, Insulin Resistance, Endothelial Function and Biomarkers of Non-alcoholic Steatohepatitis (NASH) in Obese Asian Adults	PHASE3	UNKNOWN
Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Diabetes	PHASE3	COMPLETED
Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension	PHASE2	COMPLETED
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease	EARLY_PHASE1	COMPLETED
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose	nan	COMPLETED
Kuwait Adult Diabetes Epidemiological Multidisciplinary (KADEM) Program	nan	RECRUITING
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)	nan	COMPLETED
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy	nan	NOT_YET_RECRUITING
Monitoring of Hepatic Fat Metabolism Using Magnetic Resonance Methods	nan	COMPLETED
Lysosomal Acid Lipase Activity in Nonalcoholic Fatty Liver Disease	nan	COMPLETED
Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance	nan	COMPLETED
Nutrigenetic Intervention on Blood Lipid Markers and Body Composition of Adults With Overweight and Obesity	nan	COMPLETED
National Lysosomal Acid Lipase Deficiency Study	nan	COMPLETED
Effect of Molecular Hydrogen in Patients With NAFLD	nan	COMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.	nan	RECRUITING
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity	nan	COMPLETED
Study Comparing Blood Levels of Fatty Acids After Consuming Two Forms of Cod Liver Oil	nan	COMPLETED
Effect of Short-Term Exercise Training on ATP Synthesis in Relatives of Type 2 Diabetic Humans	nan	COMPLETED
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism	nan	COMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Hepatic Glycogen and Fat Oxidation	nan	COMPLETED
Effects of Exercise on Fructose-induced Postprandial Lipemia	nan	COMPLETED
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype	nan	COMPLETED
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans	nan	COMPLETED
Fighting Fatty Liver in India	nan	UNKNOWN
Effectiveness of Nutritional Program Among Diabetic Patients	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a LIPC binder may also engage these)

Protein	Name	Similarity
O46559	—	1.000	O46559 →
P07867	—	1.000	P07867 →
Q3SZ79	—	0.997	Q3SZ79 →
P27656	—	0.997	P27656 →
LPL	Lipoprotein lipase	0.993	landscape →
Q32PY2	—	0.991	Q32PY2 →
Q29524	—	0.991	Q29524 →
P49923	—	0.991	P49923 →
Q5RBQ5	—	0.991	Q5RBQ5 →
Q53H76	—	0.990	Q53H76 →
P11602	—	0.990	P11602 →
P11153	—	0.989	P11153 →
O46647	—	0.989	O46647 →
Q8CIV3	—	0.989	Q8CIV3 →
P49060	—	0.988	P49060 →
P11151	—	0.987	P11151 →
P11152	—	0.986	P11152 →
Q5E9H0	—	0.985	Q5E9H0 →
P55031	—	0.985	P55031 →
Q06000	—	0.985	Q06000 →
P97535	—	0.984	P97535 →
Q5XGE9	—	0.982	Q5XGE9 →
Q6PA23	—	0.981	Q6PA23 →
Q9WVG5	—	0.980	Q9WVG5 →
Q6DBU8	—	0.980	Q6DBU8 →
Q8WWY8	—	0.980	Q8WWY8 →
Q8VI78	—	0.979	Q8VI78 →
Q641F6	—	0.978	Q641F6 →
Q6XZB0	—	0.978	Q6XZB0 →
Q8VBX1	—	0.978	Q8VBX1 →