Sugi Predict

Sugi Predict / Targets / LIPC

LIPC

Hepatic triacylglycerol lipase · P11150 · LIPC on Sugi Atlas →

9,242 patent compounds predicted against LIPC, 5,620 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL470957 SCHEMBL470957 0.55 9/20
SCHEMBL4513736 SCHEMBL4513736 0.40 8/20
SCHEMBL4513754 SCHEMBL4513754 0.40 8/20
SCHEMBL4513765 SCHEMBL4513765 0.40 8/20
SCHEMBL1410556 SCHEMBL1410556 0.57 7/20
SCHEMBL1410600 SCHEMBL1410600 0.55 7/20
SCHEMBL1410173 SCHEMBL1410173 0.54 7/20
SCHEMBL1410555 SCHEMBL1410555 0.53 7/20
Potassium Ion Potassium Ion (SCHEMBL1410609) 0.53 7/20
SCHEMBL1410172 SCHEMBL1410172 0.51 7/20
SCHEMBL1410302 SCHEMBL1410302 0.50 7/20
SCHEMBL1410148 SCHEMBL1410148 0.49 7/20
Potassium Ion Potassium Ion (SCHEMBL1410626) 0.41 7/20
SCHEMBL3662750 SCHEMBL3662750 0.57 6/20
SCHEMBL1410693 SCHEMBL1410693 0.45 6/20
SCHEMBL1410729 SCHEMBL1410729 0.46 5/20
SCHEMBL1885177 SCHEMBL1885177 0.44 5/20
SCHEMBL477818 SCHEMBL477818 0.54 4/20
SCHEMBL477819 SCHEMBL477819 0.54 4/20
SCHEMBL1409535 SCHEMBL1409535 0.47 4/20

Clinical trials — most relevant to LIPC by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients PHASE4WITHDRAWN
Niacin, N-3 Fatty Acids and Insulin Resistance PHASE4COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency PHASE3COMPLETED
Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency PHASE2/PHASE3COMPLETED
Comparing Effects of Liraglutide and Bariatric Surgery on Weight Loss, Liver Function, Body Composition, Insulin Resistance, Endothelial Function and Biomarkers of Non-alcoholic Steatohepatitis (NASH) in Obese Asian Adults PHASE3UNKNOWN
Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Diabetes PHASE3COMPLETED
Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension PHASE2COMPLETED
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease EARLY_PHASE1COMPLETED
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose nanCOMPLETED
Kuwait Adult Diabetes Epidemiological Multidisciplinary (KADEM) Program nanRECRUITING
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL) nanCOMPLETED
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy nanNOT_YET_RECRUITING
Monitoring of Hepatic Fat Metabolism Using Magnetic Resonance Methods nanCOMPLETED
Lysosomal Acid Lipase Activity in Nonalcoholic Fatty Liver Disease nanCOMPLETED
Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance nanCOMPLETED
Nutrigenetic Intervention on Blood Lipid Markers and Body Composition of Adults With Overweight and Obesity nanCOMPLETED
National Lysosomal Acid Lipase Deficiency Study nanCOMPLETED
Effect of Molecular Hydrogen in Patients With NAFLD nanCOMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study. nanRECRUITING
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity nanCOMPLETED
Study Comparing Blood Levels of Fatty Acids After Consuming Two Forms of Cod Liver Oil nanCOMPLETED
Effect of Short-Term Exercise Training on ATP Synthesis in Relatives of Type 2 Diabetic Humans nanCOMPLETED
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism nanCOMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
Hepatic Glycogen and Fat Oxidation nanCOMPLETED
Effects of Exercise on Fructose-induced Postprandial Lipemia nanCOMPLETED
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype nanCOMPLETED
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans nanCOMPLETED
Fighting Fatty Liver in India nanUNKNOWN
Effectiveness of Nutritional Program Among Diabetic Patients nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a LIPC binder may also engage these)

ProteinNameSimilarity
O46559 — 1.000 O46559 →
P07867 — 1.000 P07867 →
Q3SZ79 — 0.997 Q3SZ79 →
P27656 — 0.997 P27656 →
LPL Lipoprotein lipase 0.993 landscape →
Q32PY2 — 0.991 Q32PY2 →
P49923 — 0.991 P49923 →
Q29524 — 0.991 Q29524 →
Q5RBQ5 — 0.991 Q5RBQ5 →
Q53H76 — 0.990 Q53H76 →
P11602 — 0.990 P11602 →
P11153 — 0.989 P11153 →
O46647 — 0.989 O46647 →
Q8CIV3 — 0.989 Q8CIV3 →
P49060 — 0.988 P49060 →
P11151 — 0.987 P11151 →
P11152 — 0.986 P11152 →
Q5E9H0 — 0.985 Q5E9H0 →
Q06000 — 0.985 Q06000 →
P55031 — 0.985 P55031 →
P97535 — 0.984 P97535 →
Q5XGE9 — 0.982 Q5XGE9 →
Q6PA23 — 0.981 Q6PA23 →
Q9WVG5 — 0.980 Q9WVG5 →
Q6DBU8 — 0.980 Q6DBU8 →
Q8WWY8 — 0.980 Q8WWY8 →
Q8VI78 — 0.979 Q8VI78 →
Q641F6 — 0.978 Q641F6 →
Q6XZB0 — 0.978 Q6XZB0 →
Q8VBX1 — 0.978 Q8VBX1 →