SCHEMBL25960918

SCHEMBL25960918

Cc1cc(COc2cccc(C3CCN(Cc4nc5ccccc5n4CC4CCO4)CC3)n2)c(F)cc1C(=O)C1CC1

nearest known ligand 0.72

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GLP1R P43220 20/20 0.72
CYP2C8 P10632 2/20 0.63
KCNH2 Q12809 2/20 0.63
HTR1A P08908 1/20 0.63
HTR2A P28223 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29555016 0.92 GLP1R (0.85) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL24330495 0.92 GLP1R (0.85) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL29555218 0.92 GLP1R (0.85) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL24329478 0.92 GLP1R (0.85) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL29053111 0.91 GLP1R (0.75) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL24329591 0.91 GLP1R (0.75) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL29555091 0.88 GLP1R (0.77) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL25338992 0.86 GLP1R (0.82) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL29555603 0.86 GLP1R (0.82) GLP1RCYP2C8KCNH2HTR1AHTR2A
SCHEMBL24329275 0.86 GLP1R (0.82) GLP1RCYP2C8KCNH2HTR1AHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4227299-A1 BENZIMIDAZOLONE GLP-1 RECEPTOR AGONIST AND USE THEREOF Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. (CN) 2023-08-16 EP disclosed