Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596689 | 0.77 | DAO (0.34) | HSP90AA1HSP90AB1 | |
| SCHEMBL13280018 | 0.77 | DAO (0.34) | HSP90AA1HSP90AB1 | |
| SCHEMBL420145 | 0.77 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1 | |
| SCHEMBL1539292 | 0.73 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL1586062 | 0.70 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1 | |
| SCHEMBL789420 | 0.70 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 | |
| SCHEMBL4743521 | 0.69 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1 | |
| SCHEMBL18649798 | 0.68 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 | |
| SCHEMBL12047156 | 0.67 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1 | |
| SCHEMBL20879033 | 0.67 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146801-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-24 | — | — | WO | claimed |
| EP-2678014-A2 | PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | Synta Pharmaceuticals Corp. (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012141796-A2 | PROSTATE CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-10-18 | — | — | WO | disclosed |