Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788553 | 0.99 | MEN1 (0.33) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL1586236 | 0.91 | ALDH1A1 (0.33) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL1586624 | 0.89 | GAA (0.33) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL1586062 | 0.87 | HSP90AA1 (0.38) | HSP90AA1 | |
| SCHEMBL1586050 | 0.84 | — | — | |
| SCHEMBL930136 | 0.82 | MEN1 (0.36) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL13280018 | 0.81 | DAO (0.34) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL445551 | 0.80 | MEN1 (0.32) | MEN1KMT2AGAA | |
| SCHEMBL977473 | 0.79 | MEN1 (0.35) | MEN1KMT2AGAAALDH1A1POLB | |
| SCHEMBL421149 | 0.79 | MEN1 (0.32) | MEN1KMT2AGAAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146801-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-24 | — | — | WO | claimed |