Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23270808 | 0.91 | ALOX5AP (0.44) | ALOX5APKDM4EMAPTTDP1MAPK1 | |
| SCHEMBL30181540 | 0.91 | ALOX5AP (0.44) | ALOX5APKDM4EMAPTTDP1MAPK1 | |
| SCHEMBL23270786 | 0.88 | PTGES2 (0.53) | ALOX5APKDM4EMAPTTDP1MAPK1 | |
| SCHEMBL23270840 | 0.84 | ALOX5AP (0.54) | ALOX5APCYP3A4CYP2C9MEN1KMT2A | |
| SCHEMBL3103170 | 0.83 | TBXA2R (0.48) | ALOX5APNOD2KDM4EMAPTTDP1 | |
| SCHEMBL3088456 | 0.82 | TBXA2R (0.48) | ALOX5APNOD2KDM4EMAPTTDP1 | |
| SCHEMBL3094540 | 0.81 | TBXA2R (0.46) | ALOX5APNOD2KDM4EMAPTTDP1 | |
| SCHEMBL8561922 | 0.80 | PTGES2 (0.49) | ALOX5APPTGES2CCR2TBXA2RPTGS2 | |
| SCHEMBL9403254 | 0.79 | CCR2 (0.53) | ALOX5APMAPTMAPK1PTGES2CYP1A2 | |
| SCHEMBL25968196 | 0.76 | PTGES2 (0.67) | ALOX5APKDM4EMAPTTDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SHH, GLI1, SMO | ALOX5AP 3783/4885NOD2 4337/4885NOD1 4414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.