SCHEMBL25968241

SCHEMBL25968241

CC(C)C(=O)Nc1nc2c(ncn2C2(OC(F)(F)F)CO[C@H](CO[Si](C)(C)C(C)(C)C)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.41
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
MEN1 O00255 1/20 0.32
TSHR P16473 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25968249 0.84 KDM4E (0.48) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL20154986 0.83 KDM4E (0.42) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL22968567 0.80 KDM4E (0.41) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL22883220 0.78 KDM4E (0.44) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL24049314 0.76 KDM4E (0.49) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL22034213 0.76 KDM4E (0.49) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL19662703 0.76 KDM4E (0.61) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL18671304 0.76 KDM4E (0.61) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL3821420 0.76 KDM4E (0.61) KDM4ETAS1R3TAS1R1MEN1TSHR
SCHEMBL25591228 0.76 KDM4E (0.49) KDM4ETAS1R3TAS1R1MEN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230203078-A1 SYNTHESIS OF 3'N NUCLEOSIDES THROUGH OXIME INTERMEDIATES AND RELATED COMPOUNDS Janssen Biopharma, Inc. 2023-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230203078-A1 SYNTHESIS OF 3'N NUCLEOSIDES THROUGH OXIME INTERMEDIATES AND RELATED COMPOUNDS NT5C3B, PNP, NME1 KDM4E 1564/4885TAS1R3 2186/4885TAS1R1 2652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.