Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809024 | 0.90 | MAPT (0.54) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL21769296 | 0.84 | MAPT (0.53) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL27006313 | 0.83 | MAPT (0.54) | MAPTKMT2AMEN1LMNACYP1A2 | |
| SCHEMBL4755209 | 0.83 | CES2 (0.55) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL15955979 | 0.81 | MAPT (0.53) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL22684775 | 0.80 | MAPT (0.49) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL22684774 | 0.80 | MAPT (0.49) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL21176846 | 0.80 | KMT2A (0.46) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL21185442 | 0.80 | MAPT (0.49) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL8910636 | 0.80 | MAPT (0.51) | MAPTKMT2AMEN1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011144338-A1 | PYRAZOLE DERIVATIVES AS S1P1 AGONISTS | ALMIRALL, S.A. (ES) | 2011-11-24 | — | — | WO | disclosed |