Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.59 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.59 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 4/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24192731 | 0.86 | GRIA1 (0.55) | GRIA1CACNG8BRD4CREBBPPGR | |
| SCHEMBL21483771 | 0.78 | GRIA1 (0.66) | GRIA1CACNG8BRD4CREBBPPGR | |
| SCHEMBL10714302 | 0.75 | GRIA1 (1.00) | GRIA1CACNG8BRD4CREBBPPGR | |
| SCHEMBL25977402 | 0.75 | GRIA1 (0.45) | GRIA1CACNG8BRD4CREBBPPGR | |
| SCHEMBL25970414 | 0.74 | GRIA1 (0.45) | GRIA1CACNG8BRD4CREBBPPGR | |
| SCHEMBL25970325 | 0.73 | GRIA1 (0.46) | GRIA1CACNG8BRD4PGRPDE3B | |
| SCHEMBL4481831 | 0.71 | PDE3B (0.56) | GRIA1CACNG8BRD4CREBBPPGR | |
| SCHEMBL10712809 | 0.70 | GRIA1 (0.69) | GRIA1CACNG8BRD4CREBBPPGR | |
| SCHEMBL28639586 | 0.70 | GRIA1 (0.69) | GRIA1CACNG8BRD4CREBBPPGR | |
| SCHEMBL24884440 | 0.70 | GRIA1 (0.69) | GRIA1CACNG8BRD4CREBBPPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS INC (US) | 2023-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | VHL, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DLD | GRIA1 4738/4885CACNG8 1780/4885BRD4 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.