Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 8/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | POLQ | O75417 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25970436 | 0.91 | BRD4 (0.33) | GRIA1CACNG8CRBNMAP3K11AKT1 | |
| SCHEMBL24192613 | 0.87 | CRBN (0.38) | GRIA1CACNG8CRBNMAP3K11POLQ | |
| SCHEMBL25970321 | 0.84 | GRIA1 (0.39) | GRIA1CACNG8CRBNMAP3K11AKT1 | |
| SCHEMBL24192212 | 0.83 | CRBN (0.36) | GRIA1CACNG8CRBNMAP3K11POLQ | |
| SCHEMBL24192191 | 0.79 | CRBN (0.38) | GRIA1CACNG8CRBNMAP3K11POLQ | |
| SCHEMBL25977402 | 0.77 | GRIA1 (0.45) | GRIA1CACNG8CRBNPOLQ | |
| SCHEMBL25970408 | 0.75 | GRIA1 (0.33) | GRIA1CACNG8AKT1POLQ | |
| SCHEMBL24192596 | 0.75 | GRIA1 (0.37) | GRIA1CACNG8CRBN | |
| SCHEMBL25977365 | 0.74 | GRIA1 (0.34) | GRIA1CRBNAKT1 | |
| SCHEMBL24192268 | 0.73 | GRIA1 (0.35) | GRIA1CACNG8CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS INC (US) | 2023-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | VHL, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DLD | GRIA1 4738/4885CACNG8 1780/4885CRBN 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.