Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30755109 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL2597278 | 0.79 | CFTR (0.53) | KDM4EALDH1A1MAPTMEN1HPGD | |
| SCHEMBL31137279 | 0.77 | ALDH1A1 (0.53) | KDM4EALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL31500097 | 0.77 | ALDH1A1 (0.53) | KDM4EALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL17110622 | 0.77 | NOTUM (0.52) | NOTUMKDM4EALDH1A1HTTTLR2 | |
| SCHEMBL3528958 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1ALOX15PDE4APDE4B | |
| SCHEMBL2597282 | 0.75 | ALDH1A1 (0.56) | KDM4EALDH1A1HTTLMNAL3MBTL1 | |
| SCHEMBL1817901 | 0.75 | NOTUM (0.50) | NOTUMKDM4EALDH1A1HTTLMNA | |
| SCHEMBL327622 | 0.74 | PDE4A (0.54) | KDM4EALDH1A1HTTSMN1; SMN2HPGD | |
| SCHEMBL31506537 | 0.73 | TP53 (0.52) | KDM4EALDH1A1L3MBTL1JMJD6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571865-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | Novartis AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144666-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-11-24 | — | — | WO | disclosed |