Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 7/20 | 0.47 |
| ▸ | SMPD3 | Q9NY59 | 4/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30574648 | 0.91 | NTRK1 (0.51) | ATRSMPD3ATRIPIRAK4JAK2 | |
| SCHEMBL23696285 | 0.87 | ATR (0.42) | ATRSMPD3ATRIPJAK2NTRK1 | |
| SCHEMBL20015970 | 0.82 | SMPD3 (0.68) | SMPD3JAK2NTRK1 | |
| SCHEMBL22198207 | 0.82 | SMPD3 (0.68) | SMPD3JAK2NTRK1 | |
| SCHEMBL18208409 | 0.79 | SMPD3 (0.65) | SMPD3IRAK4CSNK2A2CSNK2A1 | |
| SCHEMBL24030249 | 0.79 | NTRK1 (0.64) | JAK2NTRK1 | |
| SCHEMBL12983924 | 0.77 | ATR (0.45) | ATRATRIPMTOR | |
| SCHEMBL12985222 | 0.77 | ATR (0.45) | ATRATRIPMTOR | |
| SCHEMBL23732307 | 0.77 | NTRK1 (0.54) | JAK2NTRK1 | |
| SCHEMBL21911083 | 0.77 | NTRK1 (0.54) | JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147594-A2 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |