Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.66 |
| ▸ | MTOR | P42345 | 18/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597590 | 0.90 | MTOR (0.53) | PIK3CAMTORPIK3CG | |
| SCHEMBL2597635 | 0.86 | MTOR (0.59) | PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL32186 | 0.80 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL32645 | 0.80 | PIK3CA (0.84) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL2597493 | 0.79 | MTOR (0.66) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL2597536 | 0.79 | MTOR (0.66) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| Hydrochloric Acid SCHEMBL1409129 | 0.79 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL32276 | 0.78 | PIK3CA (0.94) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL32434 | 0.78 | PIK3CA (0.90) | PIK3CAMTORPIK3CGPIK3R1PIK3CD | |
| SCHEMBL32508 | 0.78 | PIK3CA (0.94) | PIK3CAMTORPIK3CGPIK3R1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571884-A2 | MTOR SELECTIVE KINASE INHIBITORS | Xcovery Holding Company LLC (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146594-A2 | MTOR SELECTIVE KINASE INHIBITORS | XCOVERY HOLDING COMPANY, LLC. (US) | 2011-11-24 | — | — | WO | claimed |