Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 8/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25976511 | 0.89 | MAPK1 (0.57) | MAPK1GRM5EGFRDPP4DPP8 | |
| SCHEMBL14907170 | 0.78 | GRM5 (0.40) | GRM5DPP4DPP8DPP9DPP7 | |
| SCHEMBL16219073 | 0.78 | GRM5 (0.42) | GRM5DPP4DPP8DPP9DPP7 | |
| SCHEMBL27327040 | 0.75 | ADORA1 (0.48) | GRM5 | |
| SCHEMBL25976604 | 0.71 | MAPK1 (0.44) | MAPK1GRM5BTKRYR2ACHE | |
| SCHEMBL26032624 | 0.71 | MAPK1 (0.47) | MAPK1EGFRDPP4DPP8DPP9 | |
| SCHEMBL25976509 | 0.70 | MAPK1 (0.46) | MAPK1BTKRYR2ACHE | |
| SCHEMBL9382117 | 0.70 | GRM5 (0.56) | GRM5DPP4DPP8DPP9DPP7 | |
| SCHEMBL8277491 | 0.70 | HRH3 (0.48) | GRM5NPC1RAB9A | |
| SCHEMBL21452307 | 0.70 | GRM5 (0.37) | GRM5DPP4DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |