SCHEMBL2597817

SCHEMBL2597817

CCOC(=O)C(C(=O)OCC)c1ccc(NC(=O)c2cccc(C)c2-c2ccc(C(F)(F)F)cc2)c(C(=O)N(C)C)c1

nearest known ligand 0.44

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MTTP P55157 13/20 0.44
APOB P04114 11/20 0.44
SMO Q99835 11/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14778306 0.90 MTTP (0.47) MTTPAPOBSMO
SCHEMBL2597977 0.81 NR1H4 (0.51) MTTPAPOBSMO
SCHEMBL3729050 0.78 SMO (0.42) MTTPAPOBSMO
SCHEMBL2597814 0.74 MTTP (0.41) MTTP
SCHEMBL14790150 0.73 SMO (0.38) MTTPAPOBSMO
SCHEMBL16713406 0.73 MTTP (0.46) MTTP
SCHEMBL3739072 0.73 MTTP (0.51) MTTP
SCHEMBL2597683 0.72 PPARA (0.49) MTTP
SCHEMBL2597903 0.72 MTTP (0.39) MTTPAPOBSMO
SCHEMBL14790145 0.72 MTTP (0.38) MTTPAPOBSMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130072519-A1 2-PHENYL BENZOYLAMIDES CONN EDWARD LEE (US) 2013-03-21 US disclosed
US-20130072519-A1 2-PHENYL BENZOYLAMIDES CONN EDWARD LEE (US) 2013-03-21 US disclosed
WO-2011145022-A1 2-PHENYL BENZOYLAMIDES PFIZER INC. (US) 2011-11-24 WO disclosed
WO-2011145022-A1 2-PHENYL BENZOYLAMIDES PFIZER INC. (US) 2011-11-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130072519-A1 2-PHENYL BENZOYLAMIDES APOB, MTTP, HADHB MTTP 2/4885APOB 1/4885SMO 4858/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.