Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.47 |
| ▸ | BRD2 | P25440 | 7/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803409 | 1.00 | BRD4 (0.47) | BRD4BRD2BRD3SLC6A2SLC6A4 | |
| SCHEMBL1803413 | 1.00 | BRD4 (0.47) | BRD4BRD2BRD3SLC6A2SLC6A4 | |
| SCHEMBL1803411 | 1.00 | BRD4 (0.47) | BRD4BRD2BRD3SLC6A2SLC6A4 | |
| SCHEMBL1804300 | 0.81 | BRD4 (0.42) | BRD4BRD2BRD3CREBBPERN1 | |
| SCHEMBL1804297 | 0.81 | BRD4 (0.42) | BRD4BRD2BRD3CREBBPERN1 | |
| SCHEMBL1804301 | 0.81 | BRD4 (0.42) | BRD4BRD2BRD3CREBBPERN1 | |
| SCHEMBL861059 | 0.79 | HTR2C (0.37) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2598187 | 0.79 | HTR2C (0.37) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL861058 | 0.79 | HTR2C (0.37) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2598186 | 0.79 | HTR2C (0.37) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | claimed |
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |