Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.42 |
| ▸ | BRD2 | P25440 | 5/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804297 | 1.00 | BRD4 (0.42) | BRD4BRD2BRD3CREBBPERN1 | |
| SCHEMBL1804300 | 1.00 | BRD4 (0.42) | BRD4BRD2BRD3CREBBPERN1 | |
| SCHEMBL1803418 | 0.88 | GPR119 (0.47) | BRD4BRD2BRD3 | |
| SCHEMBL2598837 | 0.88 | GPR119 (0.47) | BRD4BRD2BRD3 | |
| SCHEMBL1803415 | 0.88 | GPR119 (0.47) | BRD4BRD2BRD3 | |
| SCHEMBL2599154 | 0.82 | RORC (0.37) | — | |
| SCHEMBL2597945 | 0.81 | BRD4 (0.47) | BRD4BRD2BRD3CREBBPERN1 | |
| SCHEMBL1803411 | 0.81 | BRD4 (0.47) | BRD4BRD2BRD3CREBBPERN1 | |
| SCHEMBL1803409 | 0.81 | BRD4 (0.47) | BRD4BRD2BRD3CREBBPERN1 | |
| SCHEMBL1803413 | 0.81 | BRD4 (0.47) | BRD4BRD2BRD3CREBBPERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-B1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBVIE INC (US) | 2017-08-09 | — | — | EP | disclosed |
| US-8846951-B2 | Modulators of 5-HT receptors and methods of use thereof | ABBVIE INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20110118231-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118231-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | HTR3A, HTR5A, HTR3C | BRD4 2085/4885BRD2 1985/4885BRD3 1631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.