Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.53 |
| ▸ | DRD3 | P35462 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861658 | 1.00 | DRD2 (0.53) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL2598009 | 1.00 | DRD2 (0.53) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL861657 | 1.00 | DRD2 (0.53) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL861389 | 0.91 | DRD2 (0.47) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL861388 | 0.91 | DRD2 (0.47) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL860589 | 0.91 | DRD2 (0.56) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL2598052 | 0.91 | DRD2 (0.56) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL860588 | 0.91 | DRD2 (0.56) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL2598051 | 0.91 | DRD2 (0.56) | DRD2DRD3HTR2AHTR2CHTR2B | |
| SCHEMBL860768 | 0.88 | DRD2 (0.44) | DRD2DRD3SIGMAR1PDE9ACCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | claimed |