Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | F12 | P00748 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804819 | 1.00 | HTR2C (0.41) | HTR2CHTR2AHTR2BF12MAPT | |
| SCHEMBL1804818 | 1.00 | HTR2C (0.41) | HTR2CHTR2AHTR2BF12MAPT | |
| SCHEMBL1804816 | 1.00 | HTR2C (0.41) | HTR2CHTR2AHTR2BF12MAPT | |
| SCHEMBL1806193 | 0.75 | HTR2C (0.36) | HTR2CHTR2ASLC6A3HTR1ASLC6A2 | |
| SCHEMBL1806196 | 0.75 | HTR2C (0.36) | HTR2CHTR2ASLC6A3HTR1ASLC6A2 | |
| SCHEMBL1806195 | 0.75 | HTR2C (0.36) | HTR2CHTR2ASLC6A3HTR1ASLC6A2 | |
| SCHEMBL1804490 | 0.74 | CHRNB4 (0.37) | HTR2CHTR2AHTR2BF12 | |
| SCHEMBL1804494 | 0.74 | CHRNB4 (0.37) | HTR2CHTR2AHTR2BF12 | |
| SCHEMBL1804493 | 0.74 | CHRNB4 (0.37) | HTR2CHTR2AHTR2BF12 | |
| SCHEMBL1803852 | 0.73 | ALOX5 (0.36) | SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | claimed |