Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.55 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 8/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31513725 | 0.82 | RECQL (0.60) | GRIN1GRIN2BKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23210845 | 0.82 | GRIN1 (0.61) | GRIN1GRIN2BNPBWR1MCHR1 | |
| SCHEMBL28345671 | 0.81 | RECQL (0.44) | GRIN1GRIN2BALDH1A1 | |
| SCHEMBL23210996 | 0.78 | GRIN1 (0.58) | GRIN1GRIN2BNPBWR1 | |
| SCHEMBL27717175 | 0.78 | RECQL (0.69) | GRIN1GRIN2BCNR2CNR1NPBWR1 | |
| SCHEMBL22892720 | 0.78 | NPBWR1 (0.51) | GRIN1GRIN2BCNR2NPBWR1MCHR1 | |
| SCHEMBL17395029 | 0.78 | NPBWR1 (0.48) | NPBWR1MCHR1KDM4EALDH1A1LMNA | |
| SCHEMBL30803766 | 0.77 | GRIN1 (0.58) | GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL29545049 | 0.76 | NPBWR1 (0.46) | GRIN1GRIN2BCNR2CNR1NPBWR1 | |
| SCHEMBL2598351 | 0.76 | NPBWR1 (0.49) | GRIN1GRIN2BCNR2CNR1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |