Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 18/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598349 | 0.86 | TGFBR1 (0.57) | TGFBR1CYP3A4CYP2C8P2RX7 | |
| SCHEMBL2598347 | 0.81 | TGFBR1 (0.68) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598293 | 0.81 | TGFBR1 (0.69) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598314 | 0.75 | TGFBR1 (0.55) | TGFBR1CYP3A4CYP2C8P2RX7 | |
| SCHEMBL2598316 | 0.74 | TGFBR1 (0.66) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598369 | 0.73 | TGFBR1 (0.51) | TGFBR1CYP3A4 | |
| SCHEMBL2598352 | 0.72 | TGFBR1 (0.49) | TGFBR1CYP3A4CYP2C8P2RX7 | |
| SCHEMBL2598462 | 0.72 | TGFBR1 (0.50) | TGFBR1CYP3A4CYP2C8P2RX7 | |
| SCHEMBL2598300 | 0.70 | TGFBR1 (0.61) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2596840 | 0.69 | TGFBR1 (0.58) | TGFBR1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |