Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598362 | 0.86 | TGFBR1 (0.70) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598458 | 0.82 | TGFBR1 (1.00) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2596786 | 0.80 | TGFBR1 (0.63) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598342 | 0.79 | TGFBR1 (1.00) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598344 | 0.78 | TGFBR1 (1.00) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598410 | 0.78 | TGFBR1 (0.58) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2596900 | 0.77 | TGFBR1 (0.59) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598409 | 0.76 | TGFBR1 (0.76) | TGFBR1CYP3A4CYP2C8SLC2A1 | |
| SCHEMBL2598375 | 0.76 | TGFBR1 (0.55) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598346 | 0.76 | TGFBR1 (0.55) | TGFBR1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | claimed |
| US-9073918-B2 | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-07-07 | — | — | US | disclosed |
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |