Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074472 | 1.00 | CHEK1 (0.39) | CHEK1FLT3PLK3PDPK1MAPK1 | |
| SCHEMBL14330155 | 0.73 | PLK3 (0.33) | CHEK1FLT3PLK3PDPK1MAPK1 | |
| SCHEMBL29209781 | 0.73 | GRM4 (0.34) | CHEK1FLT3PLK3MAPK1ROCK1 | |
| SCHEMBL30900898 | 0.73 | GRM4 (0.34) | CHEK1FLT3PLK3MAPK1ROCK1 | |
| SCHEMBL2242344 | 0.69 | PDPK1 (0.50) | CHEK1FLT3PLK3PDPK1MAPK1 | |
| SCHEMBL6155249 | 0.69 | LIMK1 (0.44) | CHEK1FLT3PLK3LMNADYRK1A | |
| SCHEMBL23272227 | 0.68 | GAA (0.33) | KDRAURKBMAP4K4CSF1RFGFR1 | |
| SCHEMBL10370205 | 0.68 | CHEK1 (0.66) | CHEK1FLT3PLK3PDPK1MAPK1 | |
| Hydrochloric Acid SCHEMBL7166188 | 0.67 | PI4KA (0.45) | CHEK1FLT3PLK3LMNADYRK1A | |
| SCHEMBL18417651 | 0.67 | CHEK1 (0.48) | CHEK1FLT3PLK3PDPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337660-A1 | HETEROCYCLIC DERIVATIVES AS CAMKK2 INHIBITORS | Bristol-Myers Squibb Company (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240826-A1 | HETEROCYCLIC DERIVATIVES AS CAMKK2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-11-17 | — | — | WO | disclosed |
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |