Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.44 |
| ▸ | PI4KA | P42356 | 5/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.43 |
| ▸ | XDH | P47989 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7166188 | 0.98 | PI4KA (0.45) | LIMK1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6322370 | 0.83 | DYRK1A (0.34) | LIMK1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL3113393 | 0.80 | LIMK1 (0.41) | LIMK1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL10120030 | 0.80 | PI4KA (0.44) | LIMK1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6672924 | 0.78 | CHEK1 (0.43) | LIMK1LRRK2DYRK1ACHEK1FLT3 | |
| SCHEMBL14074704 | 0.76 | FFAR2 (0.33) | LIMK1DYRK1A | |
| SCHEMBL21539447 | 0.76 | MTAP (0.39) | LIMK1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL19402816 | 0.76 | PIK3CD (0.38) | LIMK1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL14005628 | 0.76 | LIMK1 (0.38) | LIMK1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6205025 | 0.74 | HTT (0.48) | PI4KAPI4K2BPI4K2API4KBLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6679923-B2 | HAIR DYEING FORMULATION CONTAINING PYRAZOLIN-4,5-DIONES AND AT LEAST ONE AROMATIC PRIMARY AMINE ENABLES THE DYEING OF KERATIN FIBERS WITHOUT AND OXIDIZING AGENT IN SHADES WHICH ARE STRONG, VARIED, RESISTANT AND LESS SELECTIVE | L'OREAL S.A. (FR) | 2004-01-20 | — | — | US | claimed |
| US-20020194685-A1 | Composition for dyeing keratin fibres, comprising a pyrazoline-4, 5-dione and an aromatic primary amine | L'OREAL S.A. (FR) | 2002-12-26 | — | — | US | claimed |
| US-6464732-B2 | HAIR DYE MIXTURE | L'OREAL S.A. (FR) | 2002-10-15 | — | — | US | claimed |
| US-20020040508-A1 | COMPOSITION FOR DYEING KERATIN FIBRES,COMPRISING A PYRAZOLIN-4,5-DIONE AND AN AROMATIC PRIMARY AMINE | L'OREAL S.A. (FR) | 2002-04-11 | — | — | US | claimed |
| EP-1040817-B1 | Dyeing composition comprising a pyrazolo(1,5-a)pyrimidine and a monocyclic polyaminopyrimidine as oxidation bases and a coupler, and dyeing process | OREAL (FR) | 2005-02-02 | — | — | EP | disclosed |
| EP-1129690-B1 | Keratin fibre dye compositions containing indolizine cationic derivatives and dyeing method | OREAL (FR) | 2005-01-05 | — | — | EP | disclosed |
| EP-1064267-B1 | NOVEL CATIONIC COUPLING AGENTS, THEIR USE FOR OXIDATION DYEING OF KERATINOUS FIBRES, DYEING COMPOSITIONS AND DYEING METHODS | OREAL (FR) | 2004-09-29 | — | — | EP | disclosed |
| US-6679923-B2 | HAIR DYEING FORMULATION CONTAINING PYRAZOLIN-4,5-DIONES AND AT LEAST ONE AROMATIC PRIMARY AMINE ENABLES THE DYEING OF KERATIN FIBERS WITHOUT AND OXIDIZING AGENT IN SHADES WHICH ARE STRONG, VARIED, RESISTANT AND LESS SELECTIVE | L'OREAL S.A. (FR) | 2004-01-20 | — | — | US | disclosed |
| EP-1030647-B1 | DYEING COMPOSITION CONTAINING A PYRAZOLO- 1,5-a]-PYRIMIDINE AS OXIDATION BASE AND A NAPHTHALENE COUPLING AGENT, AND DYEING METHOD | OREAL (FR) | 2003-12-03 | — | — | EP | disclosed |
| EP-1030648-B1 | DYEING COMPOSITION CONTAINING A PYRAZOLO- 1,5-a]-PYRIMIDINE AS OXIDATION BASE AND A PYRIDINE COUPLING AGENT, AND DYEING METHOD | OREAL (FR) | 2003-12-03 | — | — | EP | disclosed |
| US-6572664-B2 | Oxidation dyeing of keratin fibers | L'OREAL S.A. (FR) | 2003-06-03 | — | — | US | disclosed |
| EP-0891181-B1 | KERATIN FIBRE DYE COMPOSITION CONTAINING PYRAZOLO-AZOLE COMPOUNDS, USE THEREOF AS DYE COUPLERS, AND DYEING METHOD | OREAL (FR) | 2003-05-14 | — | — | EP | disclosed |
| EP-1129690-A2 | Keratin fibre dye compositions containing indolizine cationic derivatives and dyeing method | L'OREAL (FR) | 2001-09-05 | — | — | EP | disclosed |
| EP-1129691-A2 | Compositions for dyeing keratinous fibers containing indolizine derivatives and dyeing method using same | L'OREAL (FR) | 2001-09-05 | — | — | EP | disclosed |
| US-6231623-B1 | OXIDATIVE DYES | L'OREAL S.A. (FR) | 2001-05-15 | — | — | US | disclosed |
| EP-1040817-A1 | Dyeing composition comprising a pyrazolo(1,5-a)pyrimidine and a monocyclic polyaminopyrimidine as oxidation bases and a coupler, and dyeing process | L'OREAL (FR) | 2000-10-04 | — | — | EP | disclosed |
| EP-0984007-A1 | Cationic orthophenylenediamines, their use for the oxidation dyeing of keratinous fibres, dyeing compositions and dyeing methods | L'OREAL (FR) | 2000-03-08 | — | — | EP | disclosed |
| EP-0983996-A1 | Cationic ortho-phenylenediamines, their use for oxidation dyeing of keratinous fibres, dyeing compositions and dyeing methods | L'OREAL (FR) | 2000-03-08 | — | — | EP | disclosed |
| EP-0981320-A1 | COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING A PYRAZOLIN-4,5-DIONE AND AN AROMATIC PRIMARY AMINE | L'OREAL (FR) | 2000-03-01 | — | — | EP | disclosed |
| WO-1998051268-A1 | COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING A PYRAZOLIN-4,5-DIONE AND AN AROMATIC PRIMARY AMINE | L'OREAL (FR) | 1998-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020194685-A1 | Composition for dyeing keratin fibres, comprising a pyrazoline-4, 5-dione and an aromatic primary amine | KRT18, KLK5, MARK1 | LIMK1 1731/4885PI4KA 2316/4885PI4K2B 2958/4885 |
| US-20020040508-A1 | COMPOSITION FOR DYEING KERATIN FIBRES,COMPRISING A PYRAZOLIN-4,5-DIONE AND AN AROMATIC PRIMARY AMINE | KRT18, KLK5, H1-5 | LIMK1 2159/4885PI4KA 2505/4885PI4K2B 3109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.