Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185677 | 0.92 | TGFBR1 (0.63) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598617 | 0.91 | TGFBR1 (0.74) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598334 | 0.90 | TGFBR1 (0.60) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598468 | 0.88 | TGFBR1 (0.58) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598404 | 0.87 | TGFBR1 (0.72) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL12186002 | 0.86 | TGFBR1 (0.73) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2599400 | 0.86 | TGFBR1 (0.62) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL16882087 | 0.85 | TGFBR1 (0.87) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598368 | 0.85 | TGFBR1 (0.61) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL12186079 | 0.84 | TGFBR1 (0.74) | TGFBR1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073918-B2 | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-07-07 | — | — | US | disclosed |
| US-9073918-B2 | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-07-07 | — | — | US | disclosed |
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |