Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596792 | 0.88 | TGFBR1 (0.75) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2596937 | 0.86 | TGFBR1 (0.67) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598362 | 0.81 | TGFBR1 (0.70) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2596913 | 0.79 | TGFBR1 (0.76) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL12185676 | 0.78 | TGFBR1 (0.64) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598300 | 0.78 | TGFBR1 (0.61) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL12185636 | 0.78 | TGFBR1 (0.60) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2596831 | 0.78 | TGFBR1 (0.72) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2596816 | 0.77 | TGFBR1 (0.74) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2599199 | 0.77 | TGFBR1 (0.73) | TGFBR1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | claimed |