Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598488 | 0.90 | TGFBR1 (0.67) | TGFBR1CYP3A4CYP2C8NPC1RAB9A | |
| SCHEMBL2598640 | 0.85 | TGFBR1 (0.82) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL12185615 | 0.84 | TGFBR1 (0.73) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598324 | 0.82 | TGFBR1 (1.00) | TGFBR1 | |
| SCHEMBL2598546 | 0.78 | TGFBR1 (0.82) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598308 | 0.76 | TGFBR1 (0.61) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2598352 | 0.76 | TGFBR1 (0.49) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL2599368 | 0.76 | TGFBR1 (0.85) | TGFBR1CYP3A4 | |
| SCHEMBL2598440 | 0.76 | TGFBR1 (0.71) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL12185545 | 0.76 | TGFBR1 (0.73) | TGFBR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | claimed |
| US-9073918-B2 | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-07-07 | — | — | US | disclosed |
| US-9073918-B2 | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-07-07 | — | — | US | disclosed |
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |