Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790072 | 0.79 | TP53 (0.32) | L3MBTL1TP53TDP1ALDH1A1KDM4E | |
| SCHEMBL3313643 | 0.79 | SMN1; SMN2 (0.52) | LMNAPOLBSMN1; SMN2CHRM1CHRM2 | |
| SCHEMBL799011 | 0.79 | TP53 (0.50) | TP53GPR119KDM4E | |
| SCHEMBL14795056 | 0.75 | TSHR (0.40) | SMN1; SMN2CHRM1CHRM2L3MBTL1TDP1 | |
| SCHEMBL31131213 | 0.74 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2CHRM1CHRM2 | |
| SCHEMBL2360585 | 0.74 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2CHRM1CHRM2 | |
| SCHEMBL795879 | 0.74 | TP53 (0.45) | TP53GPR119KDM4E | |
| SCHEMBL2598541 | 0.73 | — | — | |
| SCHEMBL724672 | 0.72 | SMN1; SMN2 (0.50) | LMNAPOLBSMN1; SMN2CHRM1CHRM2 | |
| SCHEMBL30121711 | 0.72 | CHRM2 (0.50) | LMNAPOLBSMN1; SMN2CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |