Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 5/20 | 0.32 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805585 | 1.00 | ACMSD (0.39) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| SCHEMBL2598841 | 1.00 | ACMSD (0.39) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| SCHEMBL1805583 | 1.00 | ACMSD (0.39) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| Hydrochloric Acid SCHEMBL2598913 | 0.99 | ACMSD (0.39) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| Hydrochloric Acid SCHEMBL1806102 | 0.99 | ACMSD (0.39) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| Hydrochloric Acid SCHEMBL2598911 | 0.99 | ACMSD (0.39) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| Hydrochloric Acid SCHEMBL1806104 | 0.99 | ACMSD (0.39) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| SCHEMBL860924 | 0.83 | BACE1 (0.41) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| SCHEMBL860923 | 0.83 | BACE1 (0.41) | ACMSDBACE1CDK8MAP4K4CLK4 | |
| SCHEMBL861233 | 0.82 | BACE1 (0.41) | ACMSDBACE1SLC5A1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |