Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.34 |
| ▸ | KDM6B | O15054 | 3/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805656 | 1.00 | HSD17B2 (0.38) | HSD17B2TERTKDM4CKDM6BMAP3K14 | |
| SCHEMBL1805655 | 1.00 | HSD17B2 (0.38) | HSD17B2TERTKDM4CKDM6BMAP3K14 | |
| SCHEMBL1805654 | 1.00 | HSD17B2 (0.38) | HSD17B2TERTKDM4CKDM6BMAP3K14 | |
| SCHEMBL1809486 | 0.84 | DRD2 (0.48) | KDM4CMAPTGRIN2BRIPK1 | |
| SCHEMBL1809487 | 0.84 | DRD2 (0.48) | KDM4CMAPTGRIN2BRIPK1 | |
| SCHEMBL1809482 | 0.84 | DRD2 (0.48) | KDM4CMAPTGRIN2BRIPK1 | |
| SCHEMBL860736 | 0.82 | DRD2 (0.43) | TRPV1 | |
| SCHEMBL860734 | 0.82 | DRD2 (0.43) | TRPV1 | |
| SCHEMBL860735 | 0.82 | DRD2 (0.43) | TRPV1 | |
| SCHEMBL1806680 | 0.78 | DRD2 (0.46) | KDM4CHCRTR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |