Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802426 | 1.00 | USP30 (0.40) | USP30DRD2DRD3HTR2BTMEM97 | |
| SCHEMBL1802430 | 1.00 | USP30 (0.40) | USP30DRD2DRD3HTR2BTMEM97 | |
| SCHEMBL1802427 | 1.00 | USP30 (0.40) | USP30DRD2DRD3HTR2BTMEM97 | |
| SCHEMBL860734 | 0.85 | DRD2 (0.43) | DRD2DRD3HTR2B | |
| SCHEMBL860735 | 0.85 | DRD2 (0.43) | DRD2DRD3HTR2B | |
| SCHEMBL860736 | 0.85 | DRD2 (0.43) | DRD2DRD3HTR2B | |
| SCHEMBL1806683 | 0.83 | DRD2 (0.46) | DRD2DRD3KDM4C | |
| SCHEMBL1806680 | 0.83 | DRD2 (0.46) | DRD2DRD3KDM4C | |
| SCHEMBL1808571 | 0.83 | DRD2 (0.46) | DRD2DRD3HTR2BKDM4CHTR1A | |
| SCHEMBL2599058 | 0.83 | DRD2 (0.46) | DRD2DRD3KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |