Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.50 |
| ▸ | DRD3 | P35462 | 7/20 | 0.50 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801902 | 1.00 | DRD2 (0.50) | DRD2DRD3PARP3PARP1S1PR1 | |
| SCHEMBL861844 | 1.00 | DRD2 (0.50) | DRD2DRD3PARP3PARP1S1PR1 | |
| SCHEMBL861843 | 1.00 | DRD2 (0.50) | DRD2DRD3PARP3PARP1S1PR1 | |
| SCHEMBL2598894 | 1.00 | DRD2 (0.50) | DRD2DRD3PARP3PARP1S1PR1 | |
| SCHEMBL1801900 | 1.00 | DRD2 (0.50) | DRD2DRD3PARP3PARP1S1PR1 | |
| SCHEMBL19818358 | 1.00 | DRD2 (0.50) | DRD2DRD3PARP3PARP1S1PR1 | |
| SCHEMBL861650 | 0.90 | DPP4 (0.46) | DRD2DRD3PARP1S1PR1S1PR5 | |
| SCHEMBL861651 | 0.90 | DPP4 (0.46) | DRD2DRD3PARP1S1PR1S1PR5 | |
| SCHEMBL861215 | 0.90 | DPP4 (0.46) | DRD2DRD3PARP1S1PR1S1PR5 | |
| SCHEMBL861216 | 0.90 | DPP4 (0.46) | DRD2DRD3PARP1S1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |