Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 5/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802179 | 1.00 | HTR2B (0.43) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL1802174 | 1.00 | HTR2B (0.43) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL1802176 | 1.00 | HTR2B (0.43) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL1805082 | 0.88 | CDC7 (0.34) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL1802260 | 0.88 | HTR2C (0.39) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL1802259 | 0.88 | HTR2C (0.39) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL1805081 | 0.88 | CDC7 (0.34) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL1805078 | 0.88 | CDC7 (0.34) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL1802258 | 0.88 | HTR2C (0.39) | HTR2BTMEM97HTR1AHTR7SIGMAR1 | |
| SCHEMBL2598994 | 0.85 | HTR1A (0.32) | HTR2BTMEM97HTR1AHTR7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |