Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598972 | 1.00 | DRD2 (0.58) | DRD2DRD3SIGMAR1HTR2AHTR2C | |
| SCHEMBL1803493 | 1.00 | DRD2 (0.58) | DRD2DRD3SIGMAR1HTR2AHTR2C | |
| SCHEMBL1806403 | 1.00 | DRD2 (0.58) | DRD2DRD3SIGMAR1HTR2AHTR2C | |
| SCHEMBL1803492 | 1.00 | DRD2 (0.58) | DRD2DRD3SIGMAR1HTR2AHTR2C | |
| SCHEMBL1806401 | 1.00 | DRD2 (0.58) | DRD2DRD3SIGMAR1HTR2AHTR2C | |
| SCHEMBL860666 | 0.88 | DRD2 (0.49) | DRD2DRD3SIGMAR1ALDH1A1MAPT | |
| SCHEMBL860667 | 0.88 | DRD2 (0.49) | DRD2DRD3SIGMAR1ALDH1A1MAPT | |
| SCHEMBL1806438 | 0.87 | DRD2 (0.44) | DRD2DRD3SIGMAR1HTR2AHTR2C | |
| SCHEMBL1803745 | 0.87 | DRD2 (0.44) | DRD2DRD3SIGMAR1HTR2AHTR2C | |
| SCHEMBL1803747 | 0.87 | DRD2 (0.44) | DRD2DRD3SIGMAR1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |