Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802635 | 1.00 | PARP1 (0.47) | PARP1SCN5ASCN9ADRD2DRD3 | |
| SCHEMBL2598990 | 1.00 | PARP1 (0.47) | PARP1SCN5ASCN9ADRD2DRD3 | |
| SCHEMBL861309 | 1.00 | PARP1 (0.47) | PARP1SCN5ASCN9ADRD2DRD3 | |
| SCHEMBL861308 | 1.00 | PARP1 (0.47) | PARP1SCN5ASCN9ADRD2DRD3 | |
| SCHEMBL1802637 | 1.00 | PARP1 (0.47) | PARP1SCN5ASCN9ADRD2DRD3 | |
| SCHEMBL2598986 | 0.88 | PARP1 (0.50) | PARP1DRD2DRD3S1PR1S1PR5 | |
| SCHEMBL861334 | 0.88 | PARP1 (0.50) | PARP1DRD2DRD3S1PR1S1PR5 | |
| SCHEMBL861333 | 0.88 | PARP1 (0.50) | PARP1DRD2DRD3S1PR1S1PR5 | |
| SCHEMBL2598984 | 0.88 | PARP1 (0.50) | PARP1DRD2DRD3S1PR1S1PR5 | |
| SCHEMBL1803161 | 0.88 | DRD2 (0.43) | PARP1SCN5ASCN9ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |