Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.55 |
| ▸ | DRD3 | P35462 | 11/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1808568 | 1.00 | DRD2 (0.55) | DRD2DRD3HTR1ASIGMAR1DPP4 | |
| SCHEMBL861011 | 1.00 | DRD2 (0.55) | DRD2DRD3HTR1ASIGMAR1DPP4 | |
| SCHEMBL1808566 | 1.00 | DRD2 (0.55) | DRD2DRD3HTR1ASIGMAR1DPP4 | |
| SCHEMBL1804307 | 0.86 | DRD2 (0.64) | DRD2DRD3 | |
| SCHEMBL1804305 | 0.86 | DRD2 (0.64) | DRD2DRD3 | |
| SCHEMBL1804302 | 0.86 | DRD2 (0.64) | DRD2DRD3 | |
| SCHEMBL1806170 | 0.85 | DRD2 (0.75) | DRD2DRD3SIGMAR1CYP2D6 | |
| SCHEMBL2598923 | 0.85 | DRD2 (0.75) | DRD2DRD3SIGMAR1CYP2D6 | |
| SCHEMBL1806173 | 0.85 | DRD2 (0.75) | DRD2DRD3SIGMAR1CYP2D6 | |
| SCHEMBL1806167 | 0.85 | DRD2 (0.75) | DRD2DRD3SIGMAR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |