Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 12/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804040 | 1.00 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2A | |
| SCHEMBL1804044 | 1.00 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2A | |
| SCHEMBL1804043 | 1.00 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2A | |
| SCHEMBL1803326 | 0.85 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2A | |
| SCHEMBL2598888 | 0.85 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2A | |
| SCHEMBL1803327 | 0.85 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2A | |
| SCHEMBL1803329 | 0.85 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2A | |
| SCHEMBL1803471 | 0.82 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2A | |
| SCHEMBL1804388 | 0.82 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2B | |
| SCHEMBL1802870 | 0.82 | ADRA2A (0.47) | ADRA2AADRA2BADRA1AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |