Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KHK | P50053 | 2/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22828466 | 0.90 | MAPT (0.43) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22828665 | 0.89 | KHK (0.42) | F2RL1KHKNTRK1GPR119IDH1 | |
| SCHEMBL25990324 | 0.83 | MAPT (0.37) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL25990533 | 0.83 | KHK (0.42) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22828461 | 0.79 | FABP4 (0.41) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL25990311 | 0.78 | KHK (0.38) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22828464 | 0.78 | KHK (0.46) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22828654 | 0.77 | MAPT (0.38) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL22828724 | 0.77 | HDAC4 (0.41) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL25990523 | 0.77 | KHK (0.42) | MAPTHPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983404-B1 | DISUBSTITUTED PYRAZOLE COMPOUNDS AS KETOHEXOKINASE INHBITORS | LILLY CO ELI (US) | 2023-08-09 | — | — | EP | disclosed |