Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.41 |
| ▸ | NRAS | P01111 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | BLK | P51451 | 2/20 | 0.39 |
| ▸ | CCNH | P51946 | 2/20 | 0.39 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25988961 | 1.00 | FLT3 (0.42) | FLT3IRAK4IRAK1NRASLCK | |
| SCHEMBL25988962 | 1.00 | FLT3 (0.42) | FLT3IRAK4IRAK1NRASLCK | |
| SCHEMBL25339825 | 1.00 | FLT3 (0.42) | FLT3IRAK4IRAK1NRASLCK | |
| SCHEMBL25989354 | 0.93 | FLT3 (0.45) | FLT3IRAK4IRAK1NRASLCK | |
| SCHEMBL25998222 | 0.93 | FLT3 (0.45) | FLT3IRAK4IRAK1NRASLCK | |
| SCHEMBL25989352 | 0.93 | FLT3 (0.45) | FLT3IRAK4IRAK1NRASLCK | |
| SCHEMBL25993184 | 0.93 | FLT3 (0.45) | FLT3IRAK4IRAK1NRASLCK | |
| SCHEMBL24231381 | 0.88 | FLT3 (0.50) | FLT3IRAK4IRAK1NRASCDK7 | |
| SCHEMBL24231327 | 0.88 | FLT3 (0.50) | FLT3IRAK4IRAK1NRASCDK7 | |
| SCHEMBL25988952 | 0.88 | FLT3 (0.50) | FLT3IRAK4IRAK1NRASCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150601-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-08-10 | — | — | WO | disclosed |