Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599387 | 0.90 | KDM4E (0.31) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL2599363 | 0.90 | KDM4E (0.33) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL2597352 | 0.84 | AR (0.35) | ARCA12CA9DDR1 | |
| SCHEMBL2597356 | 0.81 | DDR1 (0.32) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL2597292 | 0.80 | DDR1 (0.33) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL2597194 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL2597153 | 0.78 | DDR1 (0.35) | KDM4EALDH1A1HSD17B10HPGDLMNA | |
| SCHEMBL2597447 | 0.77 | DDR1 (0.34) | ARCA12CA9DDR1 | |
| SCHEMBL2597258 | 0.76 | AR (0.34) | ARCA12CA9DDR1 | |
| SCHEMBL12180764 | 0.74 | DDR1 (0.35) | ARCA12CA9DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571865-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | Novartis AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144666-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-11-24 | — | — | WO | disclosed |