Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599363 | 0.92 | KDM4E (0.33) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL2599381 | 0.90 | KDM4E (0.32) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL2597258 | 0.85 | AR (0.34) | AR | |
| SCHEMBL2597356 | 0.81 | DDR1 (0.32) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL2597292 | 0.80 | DDR1 (0.33) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL2597194 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL2597447 | 0.77 | DDR1 (0.34) | AR | |
| SCHEMBL2597153 | 0.76 | DDR1 (0.35) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL12180764 | 0.75 | DDR1 (0.35) | AR | |
| SCHEMBL12180572 | 0.72 | DDR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571865-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | Novartis AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144666-A1 | 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-11-24 | — | — | WO | disclosed |