Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10508964 | 1.00 | MEN1 (0.64) | MEN1KMT2APKMALDH1A1PTGDR2 | |
| SCHEMBL5905879 | 0.88 | ALDH1A1 (0.62) | MEN1KMT2APKMALDH1A1PTGDR2 | |
| SCHEMBL22660234 | 0.85 | KDM4E (0.48) | MEN1KMT2AALDH1A1MAPTHSPB1 | |
| SCHEMBL16388497 | 0.84 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL10788762 | 0.83 | MEN1 (0.66) | MEN1KMT2APKMALDH1A1PTGDR2 | |
| SCHEMBL4261703 | 0.82 | MAPT (0.51) | PKMALDH1A1MAPTHTTKDM4E | |
| SCHEMBL4186418 | 0.82 | MEN1 (0.64) | MEN1KMT2APKMALDH1A1PTGDR2 | |
| SCHEMBL1332207 | 0.82 | KDM4E (0.64) | MEN1KMT2AALDH1A1PTGDR2MAPT | |
| SCHEMBL9863292 | 0.81 | MEN1 (0.56) | MEN1KMT2APKMALDH1A1PTGDR2 | |
| SCHEMBL29537950 | 0.81 | MEN1 (0.56) | MEN1KMT2APKMALDH1A1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144578-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |
| EP-0162776-B1 | HETEROCYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS USEFUL AS ALDOSE REDUCTASE INHIBITORS CONTAINING THEM | LABORATOIRES UPSA (FR) | 1989-04-19 | — | — | EP | disclosed |
| EP-0162776-A2 | Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them | LABORATOIRES UPSA (FR) | 1985-11-27 | — | — | EP | disclosed |